Endocrine Abstracts

Introduction: Effects of selected drugs on the efficacy of (131I) radioiodine therapy were examined.Material and methods: The study involved 200 hyperthyroid patients, treated with radioactive iodine. They were divided into five (5) groups (40 persons in each). In group I – beside 131I, patients were additionally administered antithyroid drugs, in group II – 131I and lithium carbonate, group III – 131<...

Introduction: The influence of demographic and clinical factors on the outcome of 131I therapy in hyperthyroid patients has been examined, based on a retrospective evaluation of results obtained in patients, submitted to 131I treatment. The goal of the study was an analysis of factors, including the age and sex of patients, disease duration time, as well the hormonal status before 131I application, which could have influenced the effects of the...

Background: TSH-suppressive therapy is widely used in treatment of thyroid differentiated carcinoma. A common consequence of therapy is subclinical hyperthyroidism which may cause dysfunction of cardiovascular system, metabolism and reduction of bone mass1. Thyroid hormones are also involved in regulation of brain function2. Therefore, it is not surprising that thyroid dysfunctions are associated with frequent comorbid cognitive dysfunctions and depressio...

The effectiveness of thyroid remnants ablation with 131I after thyroidectomy for differentiated thyroid carcinoma (DTC) depends mainly on absorbed radiation dose, which is proportional to 131I uptake (Tup) and its effective half-life time (EHL) in the remnants.Aim: Assessment of endogenous TSH level increment effects on EHL of 131I and Tup in thyroid remnants after surgery for DTC.Material: Twenty-o...

Introduction: The start of GH (rhGH) treatment in children with GH deficiency (GHD) causes a significant increase in bone turnover and increases height velocity. The increase in IGF1 concentrations during rhGH treatment is a marker of the efficiency of treatment. Bone age delay at baseline is related to GHD and is a good predictor of height velocity during treatment. A significant increase in bone turnover during rhGH treatment results in an increased demand for vitamin D. It ...

Introduction: Characteristic localisations of metastases of differentiated thyroid carcinoma (DTC) include local lymph nodes, the lungs and bones, while the incidence of DTC metastases onto the liver, the brain and skin is clearly lower. The localisation of metastases in other organs, including the kidneys, is very rare.Material and methods: A case of a 73–year-old patient with thyroid oxyphilic carcinoma is reported, the case being diagnosed in 199...

Introduction: An increase of thyroid iodine uptake (Tup) is one of the symptoms of thyrocyte stimulation by means of recombinant human thyrotropin (rhTSH). Low Tup, characteristic of iodine induced hyperthyroidism, creates serious problems, when 131I is considered, making this kind of treatment difficult, if not impossible.Material and methods: We report a case of a 74 years old patient, with hyperthyroidism, induced by amiodarone administrati...

Forkhead box P3 (Foxp3) is an important regulatory factor for the development and function of T regulatory cells (Tregs). Moreover it has been established that deficiency of the Foxp3 gene in Treg cells suppresses their regulatory function leading to the development of autoimmune thyroid diseases (AITDs). The aim of our study was to estimate the association of three polymorphism of FOXP3 gene with the predisposition to GD and HT in children.<p class="abst...

Introduction: FOXP3 is a critical determinant of T regulatory cells (Tregs) development and function. Treg cells play a crucial role in modulating potentially self-reactive clones, and dysfunction of this cell type contributes to autoimmune disease such as Graves’ disease (GD) and Hashimoto’s thyroiditis (HT). The aim of our study was to estimate the association of three polymorphism of FOXP3 gene with the predisposition to GD and HT in Polish population.<p class...